The expressions that make you "you" may cause wrinkles over time. But Restylane® Refyne and Restylane® Defyne are clinically proven to soften laugh lines while helping you maintain your natural expression (1,2,3). The most commonly observed side effects are swelling, redness, pain, bruising, headache, tenderness, lump formation, and itching at the injection site. To learn more about serious but rare side effects and full Important Safety Information, visit www.RestylaneUSA.com. 1. Data on file.