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A new synthetic opioid stronger than fentanyl has been found circulating in San Francisco. Authorities say four have been arrested following the overdose death of a 16-year-old, the first known victim of the drug that is so new it's not currently considered illegal in California and test kits do not detect it. Here's what to know. #tenderloin #sanfrancisco #sf #opioid #drug #fentanylcrisis #overdoseawareness #narcan #abc7news
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Administering low-dose intravenous ketamine transforms multimodal general anesthesia by targeting central pain pathways before surgical stimulation begins. Ketamine functions as a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, dampening dorsal horn wind-up and preventing acute central sensitization (Peltoniemi et al., 2016). When combined synergistically with gamma-aminobutyric acid (GABA) receptor agonists like propofol, it produces reliable hypnotic depth and somatic analgesia
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