The name "Transforming Growth Factor" is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor mechanisms.

Mar 22, 2024 · The signal transduction of TGF-β can stimulate diverse cellular responses and is particularly critical to embryonic development, wound healing, tissue homeostasis, and immune homeostasis in...

Although initially thought to stimulate cell proliferation, just like many growth factors, it became rapidly accepted that transforming growth factor β (TGF-β) is a bifunctional regulator that either inhibits or stimulates cell proliferation.

Sep 14, 2023 · Here, we review how TGF-β coordinates multicellular response programs in health and disease and how this knowledge can be leveraged to develop treatments for diseases of the TGF-β system.

Transforming growth factor (TGF) is defined as a member of a superfamily of growth factors that modulate various processes involved in embryonic development and organogenesis, including mesodermal induction and skeletal differentiation.

Apr 29, 2025 · Transforming Growth Factor Beta (TGF-β) is a multifunctional protein that regulates cell behavior, tissue development, and immune responses. While essential for normal physiological functions, its effects can be complex, sometimes promoting health and at other times contributing to disease.

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Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three [1] different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins.

Sep 3, 2012 · The transforming growth factor (TGF-β) family of growth factors controls an immense number of cellular responses and figures prominently in development and homeostasis of most human tissues.

Dec 22, 2022 · The transforming growth factor beta (TGF-β) is a crucial cytokine that get increasing concern in recent years to treat human diseases. This signal controls multiple cellular responses during embryonic development and tissue homeostasis through canonical and/or noncanonical signaling pathways.