The Houston Texans have a critical home matchup on the horizon against the San Francisco 49ers following a less-than-ideal MNF performance, now needing to capitalize in a big way in Week 8 at the start of a three-game home stand to avoid dropping to three games under .500.

The San Francisco 49ers (5-2) visit the Houston Texans (2-4) Sunday in Week 8. Kickoff from NRG Stadium in Houston, Texas, is at 1 p.m. ET (FOX). Let's analyze BetMGM Sportsbook's NFL odds around the 49ers vs. Texans odds and make our expert NFL picks and predictions for the best bets.

The Houston Texans and San Francisco 49ers face off in Week 8 of the NFL regular season. Here's where to watch and the start time.

Texans head coach DeMeco Ryans is a former 49ers defensive coordinator under Kyle Shanahan, so San Francisco knows how difficult of a challenge it will be against Houston. Jones went into further detail about the Texans, highlighting their linebackers in particular.

A week after the San Francisco 49ers improbably dominated the NFL's second-ranked offense, they'll be given a far less formidable test when they visit the Houston Texans.

Pearsall’s absence should lead to another start for Kendrick Bourne, who has been riding a hot streak in 2025. Bourne, who rejoined the team in the offseason after a four-year stint with the New England Patriots, has 385 receiving yards on the year, second on the team behind Christian McCaffrey.

The Houston Texans are back on the field during a short week against the San Francisco 49ers to start a three-game home stand, where the pressure is high for Houston to get back on track following a 2-4 start through seven weeks.