The San Francisco 49ers have not been healthy this season, and with Fred Warner and Nick Bosa out for the season, they will ...

Here's the latest on San Francisco 49ers star wide receiver Brandon Aiyuk following a knee injury last season.

Head coach Kyle Shanahan on Friday told reporters wide receiver Brandon Aiyuk is making progress toward a return that could ...

Kyle Shanahan’s San Francisco 49ers lead the NFC West, even without one of Brock Purdy and Mac Jones’ key weapons on the ...

If the 49ers win Sunday in Houston, they’ll match their overall win total from last season and they’ll be alone atop the NFC ...

A week after the San Francisco 49ers improbably dominated the NFL's second-ranked offense, they'll be given a far less ...

Explore why 49ers' Christian McCaffrey is considered the most disappointing player this season despite leading the NFL in ...

He’s on pace to finish the season with 1,129 rushing yards and seven scores and 129 catches for 1,253 yards and seven ...

Purdy last spoke to the media on Sept. 30, although he did have a conversation with NBC sideline reporter Melissa Stark when ...

The San Francisco 49ers take on the Houston Texans at 10 a.m. PT on Sunday, Oct. 26 at NRG Stadium in Houston.

The San Francisco 49ers have a chance to raise their record to a surprising 6-2 going up against a struggling Texans team, ...

Christian McCaffrey has done everything asked of him, and more, in a season where the San Francisco 49ers have been defined ...