NEW YORK (Reuters) -Dual risks kept investors on edge ahead of markets reopening late on Sunday, from heightened prospects of a broad Middle East war to U.S.-wide protests against U.S. President Donald Trump that threatened more domestic chaos.

Israel targeted nuclear and military sites in Iran in airstrikes early Friday morning.The strikes are a major escalation that threatens to expand into a wider regional conflict.These are five key questions as the conflict continues.

Follow live updates as Iran retaliates after Israel strikes nuclear facilities. Stay informed with real-time news and developments.

Sen. Chris Murphy (D., Conn.), who sits on the Senate Foreign Relations Committee, said Israel’s attack on Iran was intended to thwart the Trump administration’s negotiations with Iran, and risks a regional war.

Israel’s leader and President Trump appeared to bet they can persevere, but other world leaders warned of unintended outcomes in a volatile region.

Trump now faces a difficult balancing act between supporting Israeli strikes and salvaging fragile nuclear negotiations with Iran, which he emphasized on Friday remain a priority.

Gold is shining as Treasurys remain under pressure — but it’s probably too soon to write off U.S. debt as a safe-haven asset.

The Dow dropped more than 750 points Friday as investors fret over the risk of a widening war in the Middle East.

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Israel’s attacks on Iran’s nuclear facilities risk pushing back the timeline for Federal Reserve interest-rate cuts as the US central bank waits to assess any potential impact on inflation, economists said.

Trump now faces a difficult balancing act between supporting Israeli strikes and salvaging fragile nuclear negotiations with Iran, which he emphasized on Friday remain a priority.

"Vladimir Putin condemned Israel's military operation against Iran and expressed serious concern about a possible escalation of the conflict," a Kremlin aide told reporters. MOSCO