gut.bmj

PDE5A + cancer-associated fibroblasts enhance immune suppression in gastric cancer

Background Gastric cancer (GC) ranks among the most prevalent lethal tumours globally. Cancer-associated fibroblasts (CAFs) are pivotal in creating an immunosuppressive tumour microenvironment (TME) ...
gut.bmj

Crosstalk between liver sinusoidal endothelial cells and hepatocytes via IL-1α–IL1R1 axis exacerbates ischaemia/reperfusion injury in aged livers

Background With population ageing, elderly patients account for a growing proportion of hepatic surgery recipients. Hepatic ischaemia-reperfusion injury (HIRI) is a major cause of postoperative liver ...
gut.bmj

Response to: Cutting waste in endoscopy: the roles of professional practice and staffing levels by Fujisawa and Fujikawa

We thank Drs Fujisawa and Fujikawa for their thoughtful comments, which highlight professional and organisational determinants that complement our data on waste generation.1 2 In our multicentre study ...
gut.bmj

Response to: ‘Lumen-apposing metal stents for pancreatic fluid collections: has advancing technology encouraged overreach?’ by Besim Fazil et al

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be ...
gut.bmj

Real-world validation of a prognostic clinical index to predict steroid response in acute severe colitis: a single tertiary centre retrospective study

We read with great interest the article by Adams et al in *Gut* on the development and validation of the Admission Model for Intensification of Therapy in Acute Severe Colitis (ADMIT-ASC) score to ...
gut.bmj

Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles

a Department of Molecular and Cellular Pathology, University of Dundee, Dundee, UK, b School of Applied Science, South Bank University, London, UK Dr M J Hopkins, MRC Microbiology and Gut Biology ...
gut.bmj

Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies

Objective Tryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed to examine relationships of host and microbial tryptophan metabolites ...
gut.bmj

The first large population based twin study of coeliac disease

1 Department of Paediatrics, University of Naples Federico II, Naples, Italy and European Laboratory of Food Induced Disease (ELFID), Naples, Italy Background and aims: The genetic load in coeliac ...
gut.bmj

Behaviour of Crohn's disease according to the Vienna classification: changing pattern over the course of the disease

BACKGROUND Crohn's disease is a heterogeneous disorder with both a genetic and environmental aetiology. Clinical classifications of the disease, such as the newly proposed Vienna classification, may ...
gut.bmj

Microbiology of bacterial translocation in humans

Background—Gut translocation of bacteria has been shown in both animal and human studies. Evidence from animal studies that links bacterial translocation to the development of postoperative sepsis and ...
gut.bmj

Deep mural injury and perforation after colonic endoscopic mucosal resection: a new classification and analysis of risk factors

Objectives Perforation is the most serious complication associated with endoscopic mucosal resection (EMR). We propose a new classification for the appearance and integrity of the muscularis propria ...
gut.bmj

Non-alcoholic fatty liver disease and increased risk of incident extrahepatic cancers: a meta-analysis of observational cohort studies

Objective We performed a meta-analysis of observational studies to quantify the magnitude of the association between non-alcoholic fatty liver disease (NAFLD) and risk of extrahepatic cancers. Design ...