We first describe the likelihood of the commonly used variance components model, for example as in Amos. 5 Since the total likelihood is a product of likelihood over all the families under study, we ...

The Annals of Applied Statistics, Vol. 11, No. 4 (December 2017), pp. 2027-2051 (25 pages) Linear mixed models (LMMs) are among the most commonly used tools for genetic association studies. However, ...

Models to estimate heritability (twin or SNP h2) are typically linear models that can be seen as extensions of the simple linear model between two variables, from which one estimates a correlation.