Iran launched missile and drone strikes on U.S. military facilities across Middle Eastern countries Friday, retaliating after U.S.-Israeli attacks.

The Middle East reacts to the U.S.-Israeli attacks on Iran which killed Supreme Leader Ayatollah Ali Khamenei.

The war with Iran is causing travel and aviation chaos in the Middle East and beyond, with flights and even airports shut down from UAE, Qatar, Kuwait, Israel, Bahrain and Iraq.

Plans for the biggest mass evacuation in a generation are being drawn up to rescue thousands of British nationals left stranded by US-Israeli strikes on Iran.

More than 100 people were injured and at least four were killed after Iran fired hundreds of missiles and drones at Gulf cities, including Dubai, Abu Dhabi and Doha.

Middle East airspace closures have created a visible gap in global flight paths, forcing long-haul reroutes, increasing fuel costs and disruption, with potential knock-on effects for schedules and fares worldwide.

Here's What We Know So Far About the Attacks:<br /><br />1. Iran strikes across Gulf: Missiles hit Abu Dhabi, Dubai, Doha, Riyadh, Bahrain and Kuwait after US-Israel strikes on Iran, marking a major escalation.

Gas prices could rise 25-50 cents per gallon as Middle East tensions threaten global oil supplies after strikes on Iran killed Supreme Leader Khamenei.