Genomes are the underlying templates for many biological processes in the nucleus that are temporally and spatially coordinated, including transcription, replication and epigenetic DNA and histone ...

This illustrative rendering of a 2.1 Mb region on chromosome 20 shows eight domains, six of which are demarcated by loops between convergent CTCF-binding sites located at the domain boundaries. The ...

The R loop is a nucleic acid ménage à trois in which RNA inserts between the two DNA strands, hybridizing with one and forcing the other to bulge out. Identifying the genomic location of R loops is ...

One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published in Nature. Subscribe to our newsletter for the latest sci-tech news updates.