A risky but often lifesaving surgery that removes damaged parts of the small intestine can leave patients facing a new threat: serious liver damage with no available treatment. Now, scientists have ...

Prev Cardiol. 2003;6(1) © 2003 Le Jacq Communications, Inc. Cite this: The Intestinal Absorption of Biliary and Dietary Cholesterol as a Drug Target for Lowering the ...

During drug development, researchers need to perform adequate nonclinical testing to ensure a drug’s safety and efficacy before starting clinical trials. An important aspect they must evaluate is a ...

New research shows that certain flavonols from everyday foods can shut down the body’s drug-resistance machinery, potentially paving the way for more effective treatments, but clinical hurdles remain.

Though studies evaluating the effects of posture on the absorption of drugs have been conducted, a systematized review revealed critical gaps in methodology. Of 18 original research articles selected ...

Before orally administered drugs can make their way throughout the body, they must first bind to membrane proteins called drug transporters, which carry compounds across the intestinal tract and help ...

Drugs that are taken orally need to pass through the lining of the gastrointestinal (GI) to be taken up. Transporter proteins found on cells that line the GI tract help with this process, but for many ...

The accumulation of fats in the liver is driven by high-fat diets and obesity, and is becoming an increasingly prevalent global health concern. Characterized by excessive fat accumulation in the liver ...

Lubiprostone has been on pharmacy shelves for nearly two decades, prescribed to help people with stubborn constipation. Nobody designed it to protect kidneys. But a randomized clinical trial published ...

The way in which the body processes cholesterol affects the risk of cardiovascular diseases. LDL cholesterol is obtained from saturated fats in food and from hepatic cholesterol synthesis. Its ...