Treatment-resistant depression (TRD) is surprisingly prevalent, with 48% suffering from this form of depressive disorder, with clear negative consequences on their wellbeing and quality of life.

When prescription depression drugs fall short in efficacy, there’s an off-label way to help them work better: add-on doses of thyroid hormone. Clinicians have long known about this approach and some ...

A new peer-reviewed analysis published in Frontiers in Nutrition offers the most comprehensive look yet at whether ...

A single intravenous infusion of DMT, a fast-acting psychedelic compound found in the Amazonian brew ayahuasca, significantly reduced depression symptoms in adults with major depressive disorder, ...

High placebo responses common in tests of neuropsychiatric drugs make any clinical trial in major depressive disorder risky. Intra-Cellular Therapies now has data showing its drug met key goals of a ...

Off-label ketamine is being increasingly used in clinical practice for treatment-resistant depression. Serial infusions of ketamine were no better than midazolam infusions for hospitalized patients ...

A year after the US Food and Drug Administration (FDA) opened the door to clinical use of lysergic acid diethylamide (LSD), US-based MindMed has launched phase 3 trials in the United States and Europe ...

Patients with major depressive disorder, including those who have not responded to first-line antidepressants, may benefit from short-term nitrous oxide treatment, a major meta-analysis led by the ...

For decades, the scientific theory of depression focused on chemicals — serotonin, norepinephrine and dopamine. Nearly every ...

Music therapy can be used alongside medication and psychotherapy to help improve depression symptoms. Learn why it helps and how to get started.