Gallstone disease is common, but its genetic basis remains incompletely understood. Here, the authors conduct a trans‑ancestry GWAS identifying 116 risk loci, linking gallstone susceptibility to lipid ...

Mutations found in roughly 20% of human cancers may promote tumor growth by changing how DNA is organized inside cells.

Scientists at the Montreal Clinical Research Institute (IRCM), led by Université de Montréal medical professor Javier Di Noia, have shed light on a fundamental mystery in immunology: How do immune ...

Researchers from the University of California San Diego and collaborators have identified a previously overlooked pattern of DNA mutations in colorectal cancer. Scientists use these patterns, known as ...

A missense mutation in the sheep MC4R gene, enriched in year-round estrus breeds, boosted receptor signaling and ...

In simple terms: a mutation is a stable change in genetic sequence that can be copied when cells or viruses replicate. Most mutations have no detectable effect, some contribute to disease, and a small ...

Every cell carries a molecular record of time. As DNA is copied, repaired and exposed to damage, mutations gradually accumulate — most harmless, some potentially consequential. A new Cell study found ...

Nearly every cell in the human body contains essentially the same genetic information, yet different cells activate different ...

Mutations found in about 20% of human cancers may promote malignant growth through a shared change in how DNA is organized, ...

Most lethal mutations in wild fruit flies are driven by newly transferred jumping genes, not small DNA errors, according to a new study from Duke University. The findings, published in PLOS Biology, ...