Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL) have addressed a long-standing challenge in the pharmaceutical industry, with the development of a two-step, one-pot method for ...

Scientists have developed stable orally available cyclic peptides with a much higher bioavailability than current ones, virtually creating a generation of drugs that can target previously untreatable ...

A discovery could speed up efforts to produce new antibiotics in the fight against antimicrobial resistance. A discovery made by scientists at King's College London could speed up efforts to produce ...

Cyclic peptides often exhibit low membrane permeability which can be significantly improved via amide-to-ester substitutions—as demonstrated by researchers from Tokyo Institute of Technology (Tokyo ...

Small-molecule drugs have been instrumental in alleviating a gamut of ailments, from heart disease to the humble headache, but some experts now think we’ve exhausted the number of targets those drugs ...

Targeted anti-cyclic citrullinated peptide (CCP) testing in people presenting to primary care with new-onset, non-specific musculoskeletal symptoms may help to identify people at high risk for ...

Identification of peripheral blood markers of disease is a significant tool in many of our rheumatologic diseases due to the relative ease of a blood draw. In rheumatoid arthritis (RA) specifically, ...