The Colts' loss clinched playoff spots for the Bills and Chargers. The 49ers had already clinched their spot in the NFC, and the win keeps them alive for an NFC West title and a shot at the No. 1 seed ...

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats and more for Colts-49ers.

The Indianapolis Colts lose to the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Score updates, ...

In order for the Colts to come away with a much-needed win, here are three keys to accomplishing that. The Colts' downfield ...

Monday Night Football in Week 16 features a battle between two playoff hopefuls in the San Francisco 49ers and Indianapolis Colts. All San Francisco has to do t ...

The Indianapolis Colts might have seen their playoff hopes evaporate after a brutal loss to the San Francisco 49ers.

DeForest Buckner offered an indication he’ll return for 2026 despite a season-ending neck injury that had him considering ...

The 49ers face the Colts in Indianapolis on Monday. We break down what the game means for the NFL playoff picture.

Colts coach Shane Steichen said DT DeForest Buckner will return from a neck injury and play vs the 49ers on Monday Night Football.

Tonight’s week 16 MNF game features two teams heading in opposite directions. In the first half of the season, the 49ers dealt with key injuries on offense, started slowly, but have since been one of ...

Indianapolis Colts vs San Francisco 49ers picks, predictions, win probabilities for NFL Week 16 Monday Night Football game on ...