49ers vs. Colts takeaways: Brock Purdy’s 5 TDs put Philip Rivers, Indy on the brink

Purdy's career night kept the 49ers in the hunt for the NFC's top seed and dampened the Colts' already faint playoff hopes.

49ers vs Colts Predictions, Picks & Best Bets for Tonight's Monday Night Football Game

Get the best 49ers vs. Colts predictions and odds ahead of Week 16 Monday Night Football on December 22, 2025. Take the Over.

Colts vs. 49ers MNF takeaways

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats and more for Colts-49ers.

Three Things We Learned From the 49ers' Win Against the Colts

It's always a terrific thing when the punter is never called upon. That is exactly what happened to the San Francisco 49ers ...

3 players to blame for Colts MNF loss to 49ers

The 49ers dealt a devastating blow to the Colts' playoff hopes on Monday night and there was plenty of blame to go around in Indianapolis.

San Francisco 49ers vs Indianapolis Colts recap today: Purdy's huge night buries Colts

The Indianapolis Colts lose to the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Score updates, highlights ...
49ers Webzone

49ers vs. Colts PFF grades: Best and worst from the game, plus snap counts

Break down the 49ers' Week 16 win with PFF grades, snap counts, and top performers—who stood out and who struggled vs. the Colts.

49ers beat Colts 48-27, Is San Francisco a dark horse Super Bowl contender? | The Herd

The San Francisco 49ers beat the Indianapolis Colts 48-27, led by Brock Purdy’s 5 TDs. Colin Cowherd asks if the now 11-4 ...

Monday Night Football predictions, picks, odds for Colts vs 49ers game

Indianapolis Colts vs San Francisco 49ers picks, predictions, win probabilities for NFL Week 16 Monday Night Football game on ...