ascopubs.org

Codon 12 K-ras mutations in plasma DNA are not an indicator of disease in non-small-cell lung cancer (NSCLC) patients

Measurements of total DNA and methylated tumor suppressor genes in the plasma of patients with metastatic non-small cell lung cancer (NSCLC) before, and after chemotherapy, as potential biomarkers for ...
ascopubs.org

Prevalence of K-RAS codon 12 mutations in locally advanced head and neck squamous cell carcinoma and influence with regards to response to chemoradiation therapy

A non-randomized single-center comparison of induction chemotherapy (IC) followed by chemoradiation (CRT) versus CRT for locally advanced (LA) squamous cell carcinoma of the head and neck (SCCHN) No ...
Nature

Codon optimization of the adenoviral fiber negatively impacts structural protein expression and viral fitness

Codon usage adaptation of lytic viruses to their hosts is determinant for viral fitness. In this work, we analyzed the codon usage of adenoviral proteins by principal component analysis and assessed ...
Nature

Evolution of termination codons of proteins and the TAG-TGA paradox

In the human genome, the fraction of synonymous codons changes monotonically with the GC content of coding sequences: with increasing the GC content the codons that are richer in GC within their ...