Diverse C-terminal variation rewires protein stability in health and disease

Proteins are the tiny machines that keep our cells running, and how long they last in the cell often determines how well they ...
ALZFORUM

C-Terminal Amidation Sends Proteins to the Shredder

Like a well-run city, healthy cells recycle their waste, breaking down and reusing damaged proteins. In the January 29 Nature, scientists led by Jeffrey Bode and Jacob Corn at the Swiss Federal ...
ALZFORUM

APP C-Terminal Fragments Stifle Calcium Flow from ER to Lysosomes

C-terminal fragments of amyloid precursor protein have been blamed for endolysosomal dysfunction in Alzheimer’s disease. Now, scientists led by Wim Annaert at KU Leuven, Belgium, claim that’s because ...
EurekAlert!

C-terminal frameshift mutations generate viable knockout mutants with developmental defects for three essential protein kinases

Beijing Zhongke Journal Publising Co. Ltd. This study is led by Professor Kabin Xie (Institute of Huazhong Agricultural University College of Plant Science and Technology, Wuhan, China).