Blood cancers such as leukemia are caused by genetic changes in the blood-forming stem cells of the bone marrow. Scientists at the University Medical Center Mainz have now shown how chronic ...

A new study has given leukemia researchers a powerful new dataset and collection of analytical methods—and a starting point for future research. One common treatment for leukemia is hematopoietic stem ...

Recent advances in imaging suggested that spatial organization of hematopoietic cells in their bone marrow microenvironment (niche) regulates cell expansion, governing progression, and leukemic ...

EMBL scientists discovered self-sustaining inflammatory circuits in the bone marrow stem cell microenvironment that precede blood cancers. The illustration shows cancer cells against a background of ...

The bone marrow is a complex tissue with distinct cellular and mechanical heterogeneity, serving as the primary site for haematopoiesis. Under certain conditions, such as on the onset of mutations to ...

Bone marrow adipocytes (BMAds) are situated within the bone microenvironment, in close proximity to bone cells, vascular structures, and hematopoietic tissues. The shift of bone marrow stromal/stem ...

Typically, bone marrow research relies heavily on animal models and oversimplified cell cultures in the laboratory. Now, researchers from the Department of Biomedicine at the University of Basel and ...

Our bone marrow the fatty, jelly-like substance inside our bones is an unseen powerhouse quietly producing 500 billion new blood cells every day. That process is driven by hematopoietic stem cells ...

Our bone marrow - the fatty, jelly-like substance inside our bones - is an unseen powerhouse quietly producing 500 billion new blood cells every day. That process is driven by hematopoietic stem cells ...

In a recently published study, researchers at Fox Chase Cancer Center revealed for the first time that cancer cells can evade anti-cancer drugs by entering and surviving within bone marrow fibroblasts ...

Researchers recently developed a bone marrow model to study how the body generates cells. Interestingly, this model is the first of its kind to be developed entirely from human cells. Not only can ...