Tillis, who is up for re-election next year in battleground North Carolina, voted against advancing a bill for Trump's domestic policy agenda Saturday evening.

President Trump says he'll meet with potential GOP primary challengers to Sen. Thom Tillis after the North Carolina Republican voted Saturday against advancing the "big, beautiful bill." Why it matters: Tillis faces one of the toughest re-election fights of any GOP senator in 2026.

U.S. Sen. Thom Tillis, a North Carolina Republican, broke with his party Saturday and said he would not support the federal “One Big Beautiful Bill Act,” the sweeping budget package that would enact much of President Donald Trump’s agenda.