Kickoff from NRG Stadium is set for 1 p.m. ET, and the Texans are 1.5-point favorites, according to the latest 49ers vs. Texans odds. The over/under for total points scored is 42. Before you make any Texans vs. 49ers picks, make sure to check out what the SportsLine Projection Model has to say.

Despite being one of the most banged-up teams in the NFL, San Francisco sits tied atop the NFC West with the Seahawks and the Rams. A big reason is the play of Jones under center. The veteran has resurrected his career in leading San Francisco forward despite injuries to a laundry list of players including Brock Purdy, Brandon Aiyuk, and Nick Bosa.

Preview the San Francisco 49ers' NFL Week 8 matchup with the Texans, including live stream, TV channel, odds, and game information.

The Houston Texans look to right the offense on Sunday when they battle the San Francisco 49ers and they'll be doing so short-handed on offense.

Pearsall’s absence should lead to another start for Kendrick Bourne, who has been riding a hot streak in 2025. Bourne, who rejoined the team in the offseason after a four-year stint with the New England Patriots, has 385 receiving yards on the year, second on the team behind Christian McCaffrey.

Ever since Kyle Shanahan took over as the head coach of the San Francisco 49ers, there has been a certain section of fans who have waited for the other shoe to drop.

San Francisco 49ers quarterback Brock Purdy has been ruled out for his team's Week 8 matchup against the Houston Texans amid his recovery from turf toe.

The San Francisco 49ers need a linebacker and it just so happens their old friend, Houston Texans head coach DeMeco Ryans, likely has one available for trade ahead of the deadline.